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Recently, a study by the team of Professor Gu Zhen from the School of Pharmacy of Zhejiang University was reported in Nature Biomedical Engineering, a sub-issue of the journal Nature
For recurrence of solid tumors
Surgery is the main choice for modern clinical treatment of cancer patients, but postoperative tumor recurrence and tumor metastasis are still the main causes of death of cancer patients
In recent years, tumor immunotherapy has become an effective means of clinical tumor treatment and has achieved exciting therapeutic effects
Can be implanted in "cell warehouse"
So is there any way to maintain the activity of CAR-T cells in the tumor microenvironment and exert the killing ability of CAR-T cells against solid tumors? Many previous studies have pointed out that CAR-T cells injected directly into the tumor site in batches will quickly lose their activity and die
Based on this idea, the researchers designed a "cell warehouse"-based local slow and controlled release technology of cells, which combines two different types of cells (CAR-T cells and anti-PD-L1 antibody-modified platelets) and encapsulated IL- 15 cytokine nanoparticles are loaded into an implantable hydrogel with good biocompatibility at the same time, and the controlled release of CAR-T cells can be achieved through the slow-release ability of the hydrogel to avoid CAR-T cells caused by rapid release.
Cells work together to inhibit tumor recurrence
In mouse experiments, this cell delivery technology has been verified against postoperative tumor recurrence
After 3 weeks of treatment, postoperative recurrence of cancer lesions in mice was significantly inhibited
At the same time, this local CAR-T delivery strategy has the effect of inhibiting distant tumors
to sum up
In this study, through a delivery strategy of "cell warehouse slow and controlled release", platelets linked to CAR-T cells and anti-PD-L1 antibodies are loaded in a hydrogel, which slowly releases CAR-T cells and blocks immune checkpoints.
