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Nature Sub-Journal: Using Human Stem Cells to Construct Embryo-like Structures

 Last Update: 2021-09-30
 Source: Internet
 Author: User

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The structure produced entirely by human stem cells is very similar to the shape of a human embryo
.

The study of human embryos is essential for understanding the early stages of human development
.

Currently, this research is conducted on excess embryos donated voluntarily by individuals undergoing IVF

Now, researchers at the California Institute of Technology have used human stem cells to create embryo-like structures
.

Unlike natural embryos formed by the combination of sperm and eggs, these structures are formed by the combination of so-called pluripotent stem cells, which have the ability to develop into special types of cells

The research was conducted in the laboratory of Magdalena Zernicka-Goetz, Professor of Biology and Bioengineering at the California Institute of Technology, and was described in a paper published in the journal Nature Communications on September 21
.

These structures are made up of a kind of pluripotent stem cells, which produce different types of cells, and then these cells self-assemble into a structure whose shape is obviously similar to an embryo, with different embryos and extra-embryonic tissues
.

Pluripotent stem cells were originally isolated from a real human embryo by other researchers and have been kept in a laboratory environment ever since

Zernicka-Goetz said: "The ability to assemble the basic structure of embryos seems to be the intrinsic properties of these early embryonic cells.
They just can't'forget'
.

" "However, either their memory is not absolutely accurate, or we have not helped the cells.

The ability to generate embryo-like structures from stem cells means that no additional donated embryos are required; in addition, these structures can be created in large numbers
.

Therefore, this model system may lead to a breakthrough in the understanding of early embryonic development that is not restricted by the limited availability of human embryos

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Reconstructing aspects of human embryogenesis with pluripotent stem cells

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