Nature Sub-journal: New contrast agent spowers early tumor detection! Tiny tumor stoves can be detected!

May 28, 2020 /
PRNewswire
2020 bioON/-early detection of tumors is very important for treating cancerResearchers at the University of California, Davis have developed a new technique that has made significant progress in using magnetic resonance imaging to identify very smalltumorfrom normal tissueThe study was published May 25 in the journal Nature Nanotechnologychemical probes that generate signals on magnetic resonance imaging (MRI) can be used to locate and imagetumorThe new study is based on a phenomenon called magnetic resonance tuning, which occurs between two magnetic elementsthe nano
scaleOne function is to enhance the signal, and the other is to extinguish the signalPrevious studies have shown that extinguishing depends on the distance between magnetic elementsThis opens up new possibilities for MRI to study non-invasive and sensitive processes of various biological processesimage source: Nature Nanotechnology a team at the University of California, Davis, has developed a probe that can produce two magnetic resonance signals that suppress each other before reaching their target position, and then both enhance the contrast between tumor and surrounding tissue They call it bidirectional magnetic resonance tuning (TMRET) Combined with specially developed imaging analysis software , this dual signal allows researchers to screen for brain tumors in mouse models with greater sensitivity "This is a significant step forward," said Yuanpei Li, associate professor of biochemistry and molecular medicine at the University of California, Davis School of Medicine and the Center for Integrated Cancer "This may help to detect very small early tumor "
two magnetic components
the detector developed by a team at the University of California, Davis, contains two components: ultra-conjugated iron oxide (SPIO) nano
particles and de-magnesium chlorochloric acid-p-Magnetic manganese (P-Mn) nano-
particles, which are encased in a lipid film Both SPIO and P-Mn give strong, independent signals on MRI, but they cancel out or extinguish each other as long as they are physically close When particles enter the tumor tissue, the fat envelope breaks down, SPIO and P-Mn are separated, and both signals appear Lee's lab focused on the chemistry of the MRI probe and developed a method for processing data and reconstructing images, known as double-contrast enhanced shadow imaging (double-contrast-enhancement minus imaging, or DESI) But in order to gain expertise in physical mechanisms, they contacted Professor Kai Liu and Professor Nicholas Curro of the Department of Physics at the University of California, Davis( who currently teaches at Georgetown University) Physicists helped clarify the mechanism of the TMRET method and improved it researchers tested the method in brain and prostate cancer cells, as well as in mice For most MRI probes, tumors emit twice as much signal as normal tissue, and the "
tumor of normal tissue" is 2 or less Using the new double-contrast nanoprobe, Li and his colleagues can increase the signal ratio to 10 Lee said the team is interested in turning the study into clinical applications, but it will require a lot of work, including toxicology testing and expanded production, before applying for approval for a new drug (Bio ValleyBioon.com) References: New double-contrast technique picks up small tumors on MRI
two-way magnetic resonance and enhancedtraction subimaging for non-and quantitative biological imaging
, Nature Nanotechnology (2020) DOI: 10.1038/s41565-020-0678-5,