Nature Sub-journal: Lysosome abnormalities cause cancer!

April 9, 2020 /
Biovalley BIOON / - Cancer cells grow and split in an uncontrolled manner A new study from Uppala University shows that changes in cell degradation centers, called lysosomes, can cause abnormal cell growth The findings were published recently in The Nature Communications normal cells have several control mechanisms to prevent them from growing uncontrolled Over the past few years, these regulatory processes have become increasingly apparent on the surface of the lysosome, a small encapsulation cystic bubble that serves as a degradation center for all cells A cell can have hundreds of lysosomes, which are organized into complex networks Cancer cells often alter the tissues of their lysosome networks, although it is not clear to what extent this will help the progression of the tumor image source: http://cn.bing.com
In this study, scientists from Uppsala University and the Weill Cornell School of Medicine in the United States found that the number of lysosomes in the lysosome network affects cell growth by activating a protein called mTOR " We found that as the number of lysosomes increased, the mTOR molecules on the surface of the lysosomes became extremely active Ander Mutvei, a researcher in the
department of
immunology and , at Uppsala University, says that because mTOR is a central irritant for cell growth, it can lead to faster cell growth Mutvei led the study with John Bleni of Weill Cornell Medical School scientists have also discovered another protein, Rap1, which regulates the number of lysosomes and their tissues in the lysosome network "Although this study is still in its early stages, it demonstrates that lysosomes play a central role in cell growth control We need more information about how changes in lysosome networks cause cancer, which we're going to test in human cancer models," Said Ander Mutvei (Bio ValleyBioon.com) References: Change in cellular svesing deity can lead to cancer
2 Mutvei, A.P., Nagiec, M.J., Hamann, J.C et al.
Rap1-GTPae control mTORC1 activity by-match lyoome organization with amino acid siwead Nat Commun 11, 1416 (2020) http://doi.org/10.1038/41467-020-15156-5