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Nature sub-journal: How to repair damaged gut?

 Last Update: 2022-03-07
 Source: Internet
 Author: User

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In a recently published article, researchers at Tokyo Medical and Dental University (TMDU) present a detailed protocol for transplanting 3D cellular structures that regenerate intestinal tissue damaged in colitis

The 3D cellular structures the team transplanted, called organoids, represent one of the biggest revolutions in biomedicine over the past decade

In this study, the researchers used intestinal organoids to replace damaged intestinal tissue, an application of regenerative medicine

The total time for rectal infusion of organoids was 10 minutes, and importantly, the researchers found that the method was reproducible under different organoid culture conditions

Shiro Yui, the study's senior author, explained: "This is a versatile protocol that has previously been used to study cellular function and forms the first human clinical trial using colon organoid transplantation for the treatment of difficult-to-treat ulcerative colons.

Satoshi Watanabe, Sakurako Kobayashi, Nobuhiko Ogasawara, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe, Kim B.

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