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Figure: A) Schematic diagram of the great cerebral veins
Source: Rudolf Wilshaw Center/University of Wurzburg
Cerebral venous thrombosis is a rare disorder of cerebral circulation that, unlike a typical stroke, affects young adults more often
Scientists from the Rudolf Virchow Center for Integrative and Translational Bioimaging at the University of Würzburg (RVZ) and the University Hospital Würzburg, in collaboration with colleagues from Tübingen and Greifswald at Transregio Center (SFB TR) 240 in collaboration, has now been able to show for the first time that activation of two specific receptors on the surface of platelets leads to cerebral venous thrombosis
Two platelet receptors interact to cause cerebral venous thrombosis
To date, the molecular mechanisms of cerebral venous thrombosis are poorly understood, and there are no suitable research models
Platelet blockade as a new treatment
With these findings, researchers are now specifically looking for active substances that block this cerebral venous thrombosis
Therefore, scientists have focused their attention on platelet receptors
The key to the success of this project is the interdisciplinary collaboration of the different research teams of the Transregio 240 Collaborative Research Center (Würzburg - Tübingen) "Platelets - Molecular, Cellular and Systemic Functions in Health and Disease" (Platelets - Molecular, Cellular and Systemic Functions), which The center has been funded by the German Research Foundation since 2018
