Nature Sub-journal Depth Analysis! A number of key measures to effectively prevent breast cancer!

, June 29, 2020 /
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BIOON/ -- In a recent review published in the international journalNature Reviews Cancer, scientists from the University of Melbourne and other institutions discussed effective steps totheprevention of breast cancerDespite decades of laboratory, epidemiological, and clinical studies, breast cancer rates are still on the rise in the global population, and breast cancer remains the leading cause of the burden of cancer-related diseases in women, with one in 20 women worldwide, one in eight in high-income countries;now researchers are fully equipped to speculate on an individual's risk of breast cancer, and the accuracy of these models is likely to continue to improve over time, especially after the inclusion of new risk factors, such as multi-gene risk and mammography density;Photo Source: Britt, K.L., et al.
In this review article, Rev: 10.1038/s41568-020-0266-x
The researchers discussed the role of risk factors in driving breast cancer, and the researchers integrated these risk factors into the assessment of individual breast cancer risks This is the first step in accurately preventing breast cancer, and the researchers assessed the effectiveness and challenges of current drugs in reducing breast cancer risk, outlined how to find and replace better strategies, and finally learned lessons from the absorption and persistence of existing drugs, as well as the priorities to be considered in developing and implementing alternativesSo far, breast cancer prevention efforts in most parts of the world have focused on targeted, population-based educational interventions, such as increased physical activity, lower BMI and alcohol intake, which will remain an appropriate component of breast cancer prevention, as they also reduce the risk of other important causes of morbidity, and researchers are now working towards enhanced prevention through systematic targeted treatment or precision preventionThe direction of this strategy, precise cancer prevention means providing the right risk reduction interventions to the right women at the right time, and an important starting point is to use systematic and accurate assessment methods to analyze each woman's risk of breast cancer, and the accuracy of current evaluation models needs to be improved, and the development of better risk assessment algorithms for specific breast cancer subtypes should probably be the first consideration for researchershas a user-friendly interface that enables both women and clinicians to identify and manage disease risk at a later stage for risk management, and implementing researchers and policy makers should consider how to apply models to populations to ensure that women who increase risk are identified at an early stage, when there is still time to reduce women's risk of breast cancer through existing proven interventionsTo effectively implement these interventions, researchers need to determine which treatments are given to patients of a determined age group to maximize their protectionPreclinical studies will inform the determination of dose regimens, which also need to be well tolerated because they are used in healthy individuals, and ultimately the researchers hope to one day use risk assessment models to not only predict whether a woman has breast cancer, but also help predict their age to apply interventions to reduce breast cancer risk within the most appropriate time frame Perfect interventions may target all molecular subtypes of breast cancer, but this seems unlikely, as different patients have different causes, so a model that can predict disease subtypes and make possible future drug applications for specific subtypes may be the best option As researchers begin to look for preventive therapies that do not rely on interference with estrogen activity, they need to know more about what factors drive an increased risk of breast cancer, and assessing the tumors of women with an increased risk of base-like breast cancer (BRCA1 mutation carriers) pre-breast tissue may help researchers identify the origin of cancer cells and develop the first cell-specific potential breast cancer prevention therapy; In addition, a variety of factors, such as BMI, age, and reproductive factors, can also alter the properties of breast epithelial cells, and if the researchers find that different groups of breast epithelial cells responsible for different breast cancer subtypes (RANK-cavity progenitor cells and base-based breast cancer, etc.) are abnormally controlled, researchers may also need to develop new preventive strategies for specific subtypes in the 20th century, the eradication or control of many deadly infectious diseases changed human health, as can be imagined With current breast cancer prevention tools and future advances in this area, we are on track to achieve effective and effective treatment of breast cancer in the 21st century, and by focusing on breast cancer risk factors and incorporating them into effective risk assessment tools, researchers will target women at higher risk of cancer, delve deeper into the mechanisms that drive breast cancer risk, or help researchers develop effective treatments to combat or manage and manage more risk patients Researchers can't reverse reproductive choices that drive hormone-reactive breast cancer, but public health awareness or preventive therapy may be important, focusing on developing improved hormone therapies that provide symptom control benefits to at-risk patients without increasing the risk of breast cancer, although this may start in high-income countries, but researchers need to take global action and prioritize women's health (BioValleyBioon.com) References: Britt, K.L., Cuzick, J and Phill
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, K Key steps for effective breast cancer cancer Nat Rev Cancer (2020) doi: 10.1038/s41568-020-0266-x
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