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A few days ago, a research paper on the coronavirus was published on Research Square, a preprint server cooperating with Nature
How the coronavirus that caused the new crown epidemic appeared in the population, new discoveries provide new hints to unravel this mystery
According to the paper, the researchers collected and tested 645 bats belonging to 46 species in Laos.
The amino acid sequences of the receptor binding domains (RBD) of these three viruses are particularly interesting because receptor binding is a key step for viruses to achieve cross-species infection and spread
These types of coronaviruses discovered in Laos indicate that these parts of SARS-CoV-2 exist in nature
The research team tested the binding efficiency of the RBD of these bat coronaviruses to the human ACE2 protein, and found that the binding affinity was equivalent to the SARS-CoV-2 strain isolated from the case in the early stage of the epidemic
In view of the above-mentioned similarities, the researchers pointed out in the paper that these viruses may have contributed to the origin of SARS-CoV-2, and may essentially constitute the risk of direct transmission to humans in the future
Before the discovery of these three coronaviruses that are very close to the new coronavirus in Laos, scientists also found a coronavirus RaTG13 in bats collected in Yunnan, China.
Dr.
Spyros Lytras, who studies virus evolution at the University of Glasgow (University of Glasgow), commented in the "Nature" news that viruses exchange RNA fragments through a process of recombination, while BANAL-103, BANAL-52 and the new coronavirus have their own genomes.
Previously, multiple research teams have also discovered some coronaviruses related to the new coronavirus in Thailand, Cambodia and other places
Note: The original text has been deleted
Reference materials:
[1] Temmam, S.
[2] Closest known relatives of virus behind COVID-19 found in Laos.
[3] Peng Zhou et al.
[4] Kefang Liu et al.
