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Written byWang CongEditor
Wang Duoyu TypesettingShui Chengwen
COVID-19 is an acute respiratory disease caused by the new coronavirus (SARS-CoV-2) infection, which may be accompanied by neurological sequelae
。 Previous studies have shown that the overall cognitive ability of severely ill patients infected with the new crown will be significantly reduced, equivalent to aging for 10 years
.
This is due to the fact that the coronavirus infects and damages the frontal cortex of the brain
, a key area of cognitive function.
But there is still a lack of molecular evidence
that the new coronavirus causes brain aging.
On December 5, 2022, researchers at Harvard Medical School published a report in Nature Aging titled Severe COVID-19 is associated with molecular signatures of aging in the human Brain's research paper
.
Through the analysis of dozens of postmortem brain samples, the study found that the expression of key genes in the brains of severely ill new crown patients was similar
to that in aging brains.
These findings help us further understand COVID-19 and help address the possible consequences
of the pandemic.
The study began two years ago, when Maria Mavrikaki saw a preprint paper describing cognitive decline
after contracting COVID.
So he decided to continue his research to explore how the new coronavirus infection causes changes in the brain
.
Maria Mavrikaki and her colleagues studied samples from the frontal cortex of the brains of 21 patients who were severely ill at the time of death and one person who was asymptomatic at the time of death, comparing these samples with brain samples from 22 people who had not been infected with the virus, in addition to brain samples from 9 people who had not been infected but had been treated on a ventilator or in the ICU
。
The research team found that genes related to inflammation and stress were more actively expressed in the brains of critically ill COVID patients, while genes related to cognitive ability and the formation of brain cell connection networks were less active
.
They also analyzed the brain tissue of 20 other people who had not been infected with the virus, 10 of whom were 38 years of age and younger when they died, and 10 of whom were 71 years of age and older
when they died.
The results showed that the brain changes of these elderly deceased patients were similar
to those of the new crown patients.
Maria Mavrikaki believes that the effect of infection with the new crown on gene expression activity may be indirectly caused by inflammation, rather than because the new crown virus enters the brain
.
To test this hypothesis, they exposed lab-grown neurons to pro-inflammatory proteins, which showed that this did affect gene expression activity
associated with aging.
The team says further research is needed to confirm whether these observed changes are transient or persistent, and it's unclear what the true consequences of these changes are
.
Link to the paper: style="letter-spacing: normal;color: rgb(136, 136, 136);font-size: 12px;" _mstmutation="1" _istranslated="1">
Open reprint, welcome to forward to Moments and WeChat groups
Wang Duoyu TypesettingShui Chengwen
COVID-19 is an acute respiratory disease caused by the new coronavirus (SARS-CoV-2) infection, which may be accompanied by neurological sequelae
。 Previous studies have shown that the overall cognitive ability of severely ill patients infected with the new crown will be significantly reduced, equivalent to aging for 10 years
.
This is due to the fact that the coronavirus infects and damages the frontal cortex of the brain
, a key area of cognitive function.
But there is still a lack of molecular evidence
that the new coronavirus causes brain aging.
On December 5, 2022, researchers at Harvard Medical School published a report in Nature Aging titled Severe COVID-19 is associated with molecular signatures of aging in the human Brain's research paper
.
Through the analysis of dozens of postmortem brain samples, the study found that the expression of key genes in the brains of severely ill new crown patients was similar
to that in aging brains.
These findings help us further understand COVID-19 and help address the possible consequences
of the pandemic.
The study began two years ago, when Maria Mavrikaki saw a preprint paper describing cognitive decline
after contracting COVID.
So he decided to continue his research to explore how the new coronavirus infection causes changes in the brain
.
Maria Mavrikaki and her colleagues studied samples from the frontal cortex of the brains of 21 patients who were severely ill at the time of death and one person who was asymptomatic at the time of death, comparing these samples with brain samples from 22 people who had not been infected with the virus, in addition to brain samples from 9 people who had not been infected but had been treated on a ventilator or in the ICU
。
The research team found that genes related to inflammation and stress were more actively expressed in the brains of critically ill COVID patients, while genes related to cognitive ability and the formation of brain cell connection networks were less active
.
They also analyzed the brain tissue of 20 other people who had not been infected with the virus, 10 of whom were 38 years of age and younger when they died, and 10 of whom were 71 years of age and older
when they died.
The results showed that the brain changes of these elderly deceased patients were similar
to those of the new crown patients.
Maria Mavrikaki believes that the effect of infection with the new crown on gene expression activity may be indirectly caused by inflammation, rather than because the new crown virus enters the brain
.
To test this hypothesis, they exposed lab-grown neurons to pro-inflammatory proteins, which showed that this did affect gene expression activity
associated with aging.
The team says further research is needed to confirm whether these observed changes are transient or persistent, and it's unclear what the true consequences of these changes are
.
Link to the paper: style="letter-spacing: normal;color: rgb(136, 136, 136);font-size: 12px;" _mstmutation="1" _istranslated="1">
Open reprint, welcome to forward to Moments and WeChat groups
