Nature: Seeing through the "trick" of cancer cells brings new hope to patients with colorectal cancer

Colon cancer is a malignant tumor of the digestive tract that occurs in the colon of the human body, mostly in the age of 40-50

Recently, the top academic journal "Nature" published three consecutive heavy articles that debunked the "trick" of cancer cells and provided new prevention strategies for people at high risk of colon cancer

As we all know, stem cells are a type of cells with infinite or immortal self-renewal ability that can produce at least one type of highly differentiated progeny cells.

The adenomatous polyposis colon (APC) disease gene in stem cells, as a tumor suppressor gene for colorectal cancer, is the most common site of germline and somatic mutations

In recent years, with the advancement of technologies such as deep-targeted DNA sequencing, researchers have noticed that cancer-related mutant genes have already been latent in normal human tissues

Of course, the research process of researchers does not stop here

Excitingly, the experiment found the key vector of Apc mutation, "NOTUM gene".

In order to further study the mechanism of the interaction between normal and malignant stem cells, researchers at the University of Amsterdam Medical Center in the Netherlands built mouse and human bowel cancer models mediated by Apc gene inactivation and found that APC-mediated β-catenin is one This kind of gene expression regulator that helps maintain the state of intestinal stem cells will actively inhibit the growth of neighboring cells and even induce the apoptosis of wild-type intestinal stem cells

Not only that, cancer stem cells carrying Apc mutations have a stronger competitive advantage compared to normal stem cells.

So far, the focus of medical research in the field of cancer has been on the promotion of immune system-mediated defenses

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Reference materials:

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[3]https://#ref-CR1

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