Nature: Scientists reveal why cancer cells evade the immune system of host bodies.

5, 2020 // -- In a recent study published in the international journal Nature, scientists from the University of Michigan and others have discovered a new association or molecular mechanism that can reveal cancer's immune system, and if we compare cancer to a series of puzzles, this study may be able to stitch them together to form a larger image landscape.
One of the main parts is the immune system and why specific immune cells stop functioning, while the other part is mainly about how histoproteins in immune cells are altered, and the third part is how cell metabolism processes and processes amino acids.
Photo Source: University of Cambridge researcher Weiping Zou says it's not known if these problems can be linked, and in this study we were able to piece together these puzzles to illustrate how they work; in the paper, researchers found a link between three separate puzzles, suggesting that targeting methionine transport proteins in tumor cells may help immunotherapy fight more effectively against more cancers.
cancer starts with the immune system's guardian, T-cells, which make these cells function abnormally and organize T-cells to attack cancer cells. At present, researchers are not very clear. In the
study, researchers carefully analyzed how tumor micro-environments, especially tumors, metabolize amino acids, and found that amino acids called methionine have the greatest impact on the survival and function of T cells, with T cells carrying lower levels of methionine becoming abnormal, and lower levels of methionine in T cells may also change the pattern of histamines, thereby contributing to T-cell damage.
Introduction of tumor cells may have recently led to a battle between tumor cells and T cells for methionine, and again and again, tumor cells will win, obtaining methionine from T cells and causing T cells to lose function.
Previously, researchers proposed a systematic way to remove methionine from cancer cells, which the researchers believe is addictive to methionine, and this study suggests that this method may be a double-edged sword, researcher Zou said, tumor cells and T cells will compete for methionine Acetaminophen, which is also needed in T cells, is not available to T cells if methionine is missing from tumor cells, so researchers want to selectively remove tumor cells between methionine and not T cells.
In fact, the results of this study show that methionine supplementation actually restores the function of T cells, and high enough levels of methionine means that both tumor cells and T cells can obtain enough methionine.
One of the key points is that tumor cells may have more transport proteins to transport methionine, and the researchers found that damage to these transport proteins may make T-cells healthier because T cells are constantly competing for methionine; Later, we need to delve deeper into why the metabolic path pathlines between tumor cells and T cells show differences, and the researchers hope to find a specific target for tumor cells that does not affect the function of T cells and kill tumor cells;
() Origins: Bian, Y., Li, W., Kremer, D.M. et al. Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Nature (2020).doi:10.1038/s41586-020-2682-1.