NATURE: Phase and formation background together shape the function of complex carcinogenic mutations
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Last Update: 2020-05-29
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Source: Internet
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Author: User
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The development of cancer is due to a sudden change in driving force, which leads to cloned proliferation and the evolution of diseaseThe discovery and functional characterization of individual lymes are the core goals of cancer research and illustrate numerous phenotypes and treatment gapsHowever, in common and rare cancer genes and tumor types, we do not know much about the sequence genetic evolution of mutated cancer genes and alleles, as well as the context in which alleles are producedrecently, researchers found that nearly a quarter of human tumors contain a compound mutation of a cancer-related gene, defined as two or more non-homogenous mutations of the same gene in the tumorcompound mutation rich in a specific gene, has a high utilization rate, the unusual hot spot mutation is driven to a certain extent by carcinogenic adaptability, and appears in the same gene configuration, reflecting the background-specific selection pressurein general, compound mutations are a driven change that comes from the specific selection pressures of backgrounds and alleles, depending in part on gene and mutation function, and leads to biological and therapeutic complexity -- often new malformations
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