NATURE: Our preference for sugar comes from the gut's drive to the brain
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Last Update: 2020-05-30
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Source: Internet
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Author: User
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The taste of sugar is one of the most basic sensory perceptions of humans and other animalsAnimals can develop a strong sugar preference, even if they lack a sweet receptor, indicating that there is a mechanism independent of taste behind itrecently, researchers have explored the neural basis of sugar preference and demonstrated that groups of neurons in the vagus nerve and brain stem are activated through the intestinal-brain axis to create a sugar preferencethese neurons are stimulated in response to sugar, but are not artificial sweeteners and can be activated by sending sugar directly to the gutusing functional imaging, the researchers monitored the activity of the intestinal-brain axis and identified lost neurons in the intestine that transmit glucose activationNext, the researchers engineered the mice to silence synaptic activity in the intestinal-to-brain neural loop and prevent the development of sugar's behavioral preferences, researchers have shown that chemical genetic activation of the loop can create a preference for other less-preferred stimuli, the findings reveal that the post-digestion sugar pathway from the gut to the brain is crucial to the development of sugarIn addition, it explains the neural basis for the difference in the behavioral effects of sweeteners and sugars, and reveals the basic circuits of the high appetite effects of sugar
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