NATURE: "One-in-one" CAR T can also reverse aging
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Last Update: 2020-06-25
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Source: Internet
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Author: User
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Cell aging is characterized by stable cell cycle stops and secretion characteristics to regulate the tissue microenvironmentPhysiologically, aging, as a tumor inhibition mechanism, can prevent the expansion of premalignaned cells and have a beneficial effect in wound healing responsepathologically, abnormal accumulation of senescent cells produces an inflammatory environment that leads to chronic tissue damage and contributes to the occurrence of diseases such as liver and pulmonary fibrosis, atherosclerosis,diabetesand osteoarthritisTherefore, in mice, the removal of senescent cells from damaged tissue can help improve these pathological symptoms and even promote longevityhere, researchers tested the idea of chimeric antigen receptor (CAR) T cells targeting senescent cells as an effective means of killing senescent cellsFirst, the researchers determined that the urinary kinase-type plasmid-activator receptor (uPAR) 11 is a cell surface protein that is widely induced during aging and shows that uPAR-specific CAR T cells can effectively ablage aging cells in vitro and in vivoUPAR-targeted CAR T cells can extend the survival of lung adenocarcinoma mice receiving aging-induced combination therapy and restore tissue balance in mice that are chemically or dietaryly induced by liver fibrosisthese results establish the potential for the treatment of senescent-related diseases in CAR T cells that target senescent cells
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