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Picture: Different types of white blood cells found in the outer layer of the mouse meninges
Source: Schafflick D, Wolbert J, Heming M, et al.
There are countless unsolved medical mysteries in the brain
"We systematically scanned the immune cells in the brain tissue and analyzed the types and numbers of cells in different parts of the tissue," explained neurologist and research leader Dr.
Capture active genes in every immune cell
In order to identify the immune cells in the tissues, the scientists used antibodies to label specific proteins present on the surface of all immune cells
"Compared with traditional RNA sequencing and other methods, analysis at the individual cell level has a decisive advantage," explained David Schafflick, a PhD student in biology
B cells and their progenitor cells are located in the outer layer of the meninges
B cells are a subclass of white blood cells, which can produce antibodies against pathogens and drive inflammation in the body
Two independent studies have reached similar results
The research team from Münster, Germany published their research results in the journal Nature Neuroscience
DOI
10.
Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges
