Nature: neem extract is expected to treat pancreatic cancer

According to a new study, natural extracts from neem tree (neem tree, or neem tree) can potentially be used to treat pancreatic cancer Relevant research results were recently published in the Journal of scientific reports The title of the paper is "nimbolide inbits pancreatic cancer growth and metastasis through ROS mediated apoptosis and investment of environmental to metabolic transition" In this study, biomedical researchers from El Paso Health Science Center of Texas Institute of technology tested whether the nimbolide found in neem leaves has the function of anti pancreatic cancer in human pancreatic cancer cell lines and mice The results showed that Azadirachtin not only prevented the growth and metastasis of pancreatic cancer, but also did not harm the normal healthy cells Rajkumar lakshmanaswamy, Ph.D., associate professor of the El Paso Center for Health Sciences at Texas Institute of technology, said, "this Azadirachtin is promising, and compared with normal cells, the specificity of this treatment for cancer cells is also very attractive." Of all cancers, pancreatic cancer has the highest mortality rate: 94% of patients die within five years of being diagnosed with pancreatic cancer The rapid growth of this cancer, there is no effective treatment, which highlights the importance of developing new therapies In this study, lakshmanaswamy and his colleagues observed that Azadirachtin reduced the migration and infiltration ability of pancreatic cancer cells by 70%, which means that these cancer cells could not become invasive or spread This is promising, the researchers say In humans, pancreatic cancer migrates and infiltrates other areas of the body, leading to death Azadirachtin treatment also induced cancer cell death, resulting in an 80% reduction in the size and number of pancreatic cancer cell colonies "Azadirachtin seems to attack pancreatic cancer in all directions," lakshmanaswamy said The researchers stressed that one of the most important findings of this study was that Azadirachtin did not harm healthy cells in vitro and in vivo Dr ramadevi subramani, a postdoctoral graduate student who is the first author of the paper, explained that "many people in India actually eat neem tree, which has no harmful side effects, suggesting that the use of neem lactone in the treatment of pancreatic cancer will not produce the adverse reactions usually produced by chemotherapy and radiotherapy." Despite these promising results, lakshmanaswamy said that there is a long way to go before Azadirachtin can be used to treat human pancreatic cancer The researchers plan to continue to study the anti-cancer mechanism behind the plant extract They will also study a variety of ways to take Azadirachtin in order to maintain its effectiveness against pancreatic cancer.