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On May 23 , 2022 , researcher Wang Yiguang and Zhang Qiang's team from the State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmacy, Peking University, and researcher You Fuping's team from the Institute of Systems Biology, Peking University published their latest research results online in Nature Nanotechnology , a top journal in the nano fie.
Pyroptosis is a newly discovered mode of programmed cell necrosis, which plays an important role in various pathophysiological processes such as pathogen infection, atherosclerosis, organ failure and tumor treatme.
In view of this, based on the ultra- pH -sensitive ( UPS ) nanotechnology platform developed by the research group, Wang Yiguang's research team is the first in the world to establish a series of nanomedicines with different pH transition points ( pH t 0–0 ) ( ANPS ), capable of dividing the intracellular early endosome - late endosome - lysosome pathway into up to 10 stages with a pH difference of only 2 units in each sta.
Using this technology, Wang Yiguang's research team discovered for the first time in the world that the process of cell endocytic maturation can spatiotemporally manipulate nanomedicine-induced cell death signaling pathways and cell killing effects, and systematically elucidated that the reactive oxygen species targeted by early endosomes are specifically Sexual activation of the phospholipase C signaling pathway on the endosome membrane and the downstream Caspase3/GSDME signaling pathway triggers efficient tumor cell pyroptosis; while the targeted delivery of reactive oxygen species to the late endosome and lysosomal stages is carried out by classical The increased permeability of the lysosomal membrane causes an inefficient mode of apoptos.
Researcher Wang Yiguang, Professor Zhang Qiang and Researcher You Fuping of the Institute of Systems Biomedicine are the corresponding authors of this paper, and .
Paper link: https:// Contributed by State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmacy)
