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Scientists from the Massachusetts Institute of Technology and the University of Manchester have developed a new method that uses healthy or cancerous pancreatic cells to grow pancreatic organoids
Using a special gel that mimics the extracellular environment around the pancreas, researchers can cultivate pancreatic organoids, which helps to study important interactions between pancreatic tumors and their environment
Professor Linda Griffith of the Massachusetts Institute of Technology Department of Bioengineering said: “Repeatability is a big issue
This paper was published in the journal Nature Materials on September 13
Simulated microenvironment
Laboratories usually use commercially available tissue-derived gels to cultivate organoids
About 10 years ago, Griffith's laboratory began to design a synthetic gel that could be used to cultivate epithelial cells
A key feature is the presence of peptide ligands, which interact with integrins on the cell surface
In this new study, Griffith and Jørgensen wanted to see if this gel can also support the growth of normal pancreatic organoids and pancreatic tumors
Jørgensen said: "We got the solution from Linda, and we put the reagents in and it worked
Jorgensen's laboratory compared the cultured organoids with mouse pancreatic tissue and found that tumor organoids expressed many of the same integrins as pancreatic tumors
Patient-derived cells
The researchers also showed that they can use the gel to grow organoids from patients' pancreatic cancer cells
Griffith also plans to use the gel to cultivate and study tissues in patients with endometriosis
One of the advantages of the new gel is that it is completely artificially synthesized and can be easily prepared in the laboratory by mixing specific precursors (including polyethylene glycol and some peptides)
###
Below, CR, Kelly, J.
, Brown, A.
et al.
A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids.
Nat.
Mater.
(2021).
https://doi.
org/10.
1038/s41563 -021-01085-1
