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Image: St.
Source: St.
Scientists at St.
Antigens are molecules that the immune system uses to recognize threats, such as infections
"If you become infected, the vaccine will still activate and amplify your immune response in a protective way," said co-corresponding author Paul Thomas, PhD, of St.
The right tool for understanding T cells
The study used data from the COVID-19-Related Immune Response Tracking Study (SJTRC)
"This creative and comprehensive T-cell work underscores the importance of a prospective study design that allows us to collect samples before participants become infected with COVID-19," said co-corresponding author Dr.
The researchers used specialized techniques to determine which small viral fragments were recognized by T cells in different populations
"We have a lot of tools and techniques that allow us to efficiently analyze T-cell receptors and identify receptors that may be different but have essentially the same function," Thomas said
Benefits of getting vaccinated
The results showed that the order of exposure (vaccination or infection came first) determined whether the immune response was skewed towards the spike protein
"A proper understanding of the T-cell response to COVID-19 infection and vaccination is indeed challenging, but it is critical to developing a strategy for long-term control of the virus," Wolf said
article title
SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells
