-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Many processes that sustain our lives also put us at risk
Cells solve this problem by synthesizing antioxidants and compounds that neutralize free radicals
Rockefeller University assistant professor Kivan Birsoy said: "With the identification of potential transporters, we can now control the amount of glutathione entering the mitochondria and specifically study the source of oxidative stress
Enter the mitochondria
In order to avoid oxidative stress, cells need to properly balance the levels of free radicals and antioxidants in the mitochondria, where energy is produced
To clarify this process, Birsoy's team monitored the expression of proteins in cells in response to glutathione levels
The analysis results point to SLC25A39, which is a protein on the mitochondrial membrane, the function of which is not yet known
The discovery of this transporter may help to better understand various disease pathways related to oxidative stress, including pathways related to aging and neurodegeneration
In addition, the team is currently exploring whether SLC25A39 has the potential to become a drug target for the treatment of cancer, by helping to induce lethal oxidative stress on tumor cells
DOI
10.
