-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
DNAzymes-a word composed of DNA and enzymes-are DNA sequences with catalytic activity
Its purpose is to target unwanted RNA molecules in viruses, cancers or damaged nerve cells, using DNAzymes to attack and destroy them
The benefits of this therapy are obvious: unwanted RNA can be precisely destroyed, while other useful RNA strands in the cell remain intact
Dr.
In their research, authors from HHU and a team from the Jülich Research Center (FZJ), the University of Bonn, and a Swiss company tried to understand how the system as a whole works dynamically, and what steps take place in the process of combining and disintegrating.
The researchers observed this process at atomic resolution and performed some real-time observations using a high-resolution nuclear magnetic resonance (NMR) spectrometer
The team of Dr.
Doctoral researcher Jan Borggrafe Etzkorn's working group and the first author of the study explained why DNAzymes do not work in cells: "We confirmed that magnesium, as an important cofactor, plays a variety of important mechanisms, but binds DNAzyme relatively poorly.
The next step is to conduct structural studies on cell culture and organoids
Dr.
Journal Reference :
Jan Borggräfe, Julian Victor, Hannah Rosenbach, Aldino Viegas, Christoph GW Gertzen, Christine Wuebben, Helena Kovacs, Mohanraj Gopalswamy, Detlev Riesner, Gerhard Steger, Olav Schiemann, Holger Gohlke, Ingrid Span, Manuel Eresolved Span, Time-resolved structural analysis.
