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It is well known that certain small differences in DNA sequence may increase a person's risk of developing Alzheimer's disease or Parkinson's disease
The researchers analyzed microglia in different regions of the brain of deceased patients with neuropsychiatric and neurodegenerative diseases
The research was led by Katia de Paiva Lopes, PhD, Gijsje Snijders, PhD, and Jack Humphrey, PhD, who work in the labs of Towfique Raj, PhD, associate professor of neuroscience, and Lotje D.
Microglia, shaped like octopuses, are found throughout the brain
Recently, this view has begun to change
In this study, scientists used advanced genomics techniques to delve into the multiple roles that microglia may play in the brain
Specifically, they obtained 255 samples from 100 donors, representing 4 different brain regions
Overall, these findings support both previous findings and new findings
The results further suggest that microglia may be involved in some cases of Alzheimer's disease and Parkinson's disease, as well as other diseases, including multiple sclerosis, schizophrenia and bipolar disorder
Finally, the researchers identified two new genes that may be involved in brain disorders
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Lopes, KdP, Snijders, GJL, Humphrey, J.