Nature Genetics: Breast cancer can be divided into 9 "ecotypes"

A research team led by the Gavin Institute of Medical Research in Australia has revealed a new method of classifying breast cancer subtypes based on cell atlases, which may help patients with personalized treatment

By analyzing breast cancer biopsy samples from patients in Sydney Hospital, the researchers revealed more than 50 different cancer, immune and stromal cell types and states, which can divide breast cancer into nine cancer "ecotypes", each All are related to different cancer prognosis

Senior author Alex Swarbrick, an associate professor at the Gavin Institute of Medical Research, said: "Our research reveals how to group cancer cell models.

Breast cancer can currently be divided into three clinical subtypes (luminal, HER2+ and triple negative), based on the specific receptors they produce

The researchers used single-cell and spatial genomics techniques to evaluate biopsy samples from 26 breast cancer patients

Co-first author Ghamdan Al-Eryani said: “We looked at the complete cell profile of each breast cancer sample and found that there were more than 50 different cell types or cell states

"Each ecotype directly corresponds to a different clinical outcome of the patient, so we think this may help determine which treatment the tumor responds best," added co-first author Dr.

The research team will next explore how to introduce this ecological typing method into the clinical diagnosis process

"Tumors are not composed of a single type of cell, but a complex mixture of cancer, immune, and stromal cells, all of which play a role in tumor progression and prognosis

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Wu, SZ, Al-Eryani, G.