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Nature: For the first time, it is clear that mitochondrial damage of neurons causes Parkinson's disease

 Last Update: 2021-11-11
 Source: Internet
 Author: User

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For patients with advanced Parkinson's disease, the drug levodopa becomes less effective in relieving symptoms due to the inevitable loss of dopamine-releasing neurons

Levodopa (levodopa) is one of the most commonly used drugs in the treatment of Parkinson's disease

Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra

In the same study, they also explained why dopaminergic neurons disappear

This study on mice was published in the journal Nature on November 3, and it is expected to discover Parkinson's disease patients five years in advance, develop therapies to slow the progression of the disease, and treat patients with advanced disease

The loss of functional mitochondrial complex I in substantia nigra dopaminergic neurons is a hallmark of Parkinson's disease

They found that the destruction of the energy factories (the mitochondria) in dopaminergic neurons is enough to cause Parkinson's disease

Corresponding author D.

"For a long time, people have been arguing whether mitochondrial damage is the cause or consequence of the disease

Researchers proved that a gene therapy targeting the substantia nigra effectively improves the effect of levodopa

Surmeier said: "This new model can help us develop tests to identify those who may be suffering from Parkinson's disease in the next 5 to 10 years

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González-Rodríguez, P.

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