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"Nature": ctDNA testing helps personalized diagnosis and treatment of bladder cancer

 Last Update: 2021-07-31
 Source: Internet
 Author: User

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Globally, there will be approximately 573,000 bladder cancer patients and 212,000 deaths in 2020

In order to identify patients with increased likelihood of residual disease after surgery, a blood test is used to detect the presence of circulating tumor genes (ctDNA)

CtDNA from solid tumors is released into the blood

According to a clinical study conducted by Queen Mary University of London, blood tests related to ctDNA may be able to identify the risk of cancer recurrence and guide the precise treatment of bladder cancer after surgery.

Detection of ctDNA shortly after surgery may overcome clinical limitations.

Thomas Powles et al, ctDNA guiding adjuvant immunotherapy in urothelial carcinoma, Nature (2021).

The researchers evaluated the treatment results of patients (581 people) in the randomized phase III trial (IMvigor010) and phase II study (ABACUS), and analyzed whether the drug Atezolizumab can reduce the recurrence of high-risk invasive urothelial cancer

The research team found that patients who were positive for ctDNA in their blood after surgery had a higher risk of cancer recurrence than those who were negative for ctDNA

Patients who are positive for ctDNA in their blood after surgery have a higher risk of cancer recurrence than those who are negative for ctDNA

Patients with ctDNA positive have improved disease-free survival and overall survival in the atezolizumab treatment group

The adjuvant use of atezolizumab may be related to improving the prognosis of patients

ctDNA testing is more accurate than traditional radiology in identifying disease recurrence

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