Nature Communications systematically uncovers features of chromatin openness in pancreatic cancer

Pancreatic cancer is one of the most malignant tumors with a 5-year survival rate of only 9%

The research team constructed 84 pancreatic tumor organoids (75 ductal adenocarcinomas, 4 intraductal papillary mucinous tumors, 1 acinar cell carcinoma, and 4 neuroendocrine tumors) and 6 normal pancreatic tissue organoids.

Integrating and analyzing multi-omics data such as chromatin openness, transcriptomics and genome-wide data, it was found that among a large number of non-coding region mutations, about 1516 (0.

This study systematically revealed the chromatin openness of pancreatic cancer for the first time through an organoid model; revealed the gene regulatory network and potential treatment of different subtypes of pancreatic cancer by integrating multi-omics data such as genomics, transcriptomics and drug sensitivity Targets; suggesting that chromatin openness is of great value for in-depth understanding of the biological behavior of pancreatic cancer, laying a solid foundation for exploring new therapeutic targets and strategies for pancreatic cancer

Gao Dong, a researcher at the Center of Excellence for Molecular Cells, Jin Gang, a professor at the Department of Hepatobiliary, Pancreatic, Pancreatic and Spleen Surgery of Shanghai Changhai Hospital, Wang Yong, a researcher at the Institute of Mathematics and Systems Science, Chinese Academy of Sciences, and Chen Luonan, a researcher at the Center of Excellence for Molecular Cells are the co-corresponding authors of the paper

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