Nature Commnications: Ranking of the most common gene mutations in all cancers

As we all know, cancer is usually caused by gene mutations caused by various reasons, but which genes are most frequently mutated in cancer? You may not expect that this genetic problem is still unanswered in the rapid development of cancer genomics

Recently, researchers from the University of Virginia and the Salk Institute published a research paper titled Cancer gene mutation frequencies for the US population in the journal Nature Commnications

This paper answers a very basic question: What are the most common mutated genes in human cancers?

The research team combined gene mutation information with cancer prevalence data to reveal the genetic basis of cancer in the entire U.

Gene mutations play a vital role in the occurrence and development of cancer, and these mutated genes can also be used as effective therapeutic targets

Although many studies have identified the genetic mutations involved in certain cancers, there is no research system to reveal which genetic mutations are most common in the entire cancer patient population

In this new study, the research team combined genomics and epidemiological cancer research data sets to determine what percentage of all cancer patients will have which genetic mutations

At first, the research team thought that this work seemed simple, but soon after they started, they discovered the problem: genomics and epidemiological research did not use a universal nomenclature system for various cancers

In order to overcome this challenge, the research team carefully analyzed more than 200 studies and individually reviewed and reclassified each cancer according to the universal naming system, and then performed data comparison and statistical analysis

The research team found that the most common gene mutation in cancer is TP53 (34.

The most common mutation gene TOP50 in cancer

Specific data on TOP25, the most common mutation gene in cancer

This is the first time that the frequency and proportion of genetic mutations have been evaluated in all cancers.

Original source:

Mendiratta, G.