Nature: Chinese team finds a large number of new human crown sympathies and antibodies to announce the mechanism of effectiveness

Today, the leading academic journal Nature published several scientific papers from the Chinese team onlineAmong them, a paper jointly brought by Tsinghua University and Shenzhen National Center for Clinical Medicine for Infectious Diseases found a number of antibodies with the potential of medium and new coronaviruses, and revealed the mechanism of neutralizing the role of these antibodiesThe antibodies mentioned in the paper are expected to be used in subsequent clinical development against new coronary disease, the researchers saidIn the study, the scientists isolated blood samples from eight patients infected with the new crown and isolated B-cells that identified the fluorescent receptor binding domain (RBD) probeFrom this, the team further identified 206 monoclonal antibodies capable of specifically targeting RBD, and found that the neutralization activity of these antibodies was related to their competitiveness and ace2's competitiveness (both combined with THE RBD of the new coronavirus)from these antibodies, the researchers wanted to obtain the crystal structure of their binding to the new coronavirus RBD, and successfully parsed the crystal structure of one of the antibody Fab segments called "P2B-2F6" that binds to RBD at a resolution of 2.85 EBy analyzing the complex structure and compared the structure of ACE2 with the new coronavirus RBD, the researchers found that when the antibody binds to RBD, it produces spatial bit resistance that prevents RBD from binding to its receptor ACE2, thus blocking the virus from entering the cellThis also explains the mechanism of how these antibodies can specifically neutralise and neo-coronavirusesIn summary, the researchers isolated 206 monoclonal antibodies from eight new coronary infections with specific binding to neo-coronavirus RBD and found that their activity was associated with competition with ACE2By analyzing the complex structure of a powerful antibody and RBD, the researchers determined that it could block the binding of RBD to ACE2 receptorsIn addition, the researchers added that different antibodies, the epitopes of which are identified, varyThis may mean that these antibodies can form synergies to treat new coronavirus infections in a multi-pronged waysurprisingly, these antibodies do not appear to have cross-active sars viruses and MERS viruses, which may indicate that, despite similar sequences, there is still a difference in immunity between different viruses, RBDIf that's the case, then we need to develop specific therapies for each virus in treating diseases caused by coronavirusesOn a certain level, this can also answer why some antibodies against SARS virus cannot neutralise and neo-coronavirusesfinally, the researchers believe that antibodies to different viruses, RBD, can be inhibitors of virus-specificAntibodies found in the paper are expected to be used in subsequent clinical development We are also looking forward to hearing the good news that they are entering the clinic soon (Original title: Zhang Linxuan/Zhang Zheng/Wang Xinquan Task Force "Nature" issued: find a large number of new human crown neutralizing antibodies, but also found their mechanism of effectiveness)