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Nature Chemical Biology Yi Chengqi research group develops double-pegRNA-mediated high-efficiency guided editing

 Last Update: 2021-11-15
 Source: Internet
 Author: User

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On October 28, 2021, the Peking University School of Life Sciences and the Peking University-Tsinghua Life Sciences Joint Center Yi Chengqi research group published a research paper entitled "Increasing the efficiency and precision of prime editing with guide RNA pairs" in Nature Chemical Biology.

Prime Editing can realize all 12 kinds of base substitutions, and can also realize the insertion and deletion of small fragments

In this study, two pegRNAs targeted to the double-stranded DNA were designed to edit the same site in the genome, so as to improve the efficiency of guided editing

Diagram of the working principle of the HOPE strategy

In summary, this study uses the dual pegRNA strategy to significantly improve the efficiency of guided editing

Professor Yi Chengqi from Peking University School of Life Sciences and Peking University-Tsinghua Life Sciences Joint Center is the corresponding author of this article

Link to the paper: https://

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