Nature Cancer: Breakthrough! New method transforms colon cancer cells into normal cells!

April 14, 2020 /PRNewswire
2020 / -- Using an improved natural substance and current methods could improve the treatment of colon cancer, according to biologists at the University of California, Irvine The findings stem from their study of the role of an amino acid in the development of tumors and potential ways to reverse the process Their paper was published in the journal Nature Cancer Colon cancer is the second leading cause of cancer-related death in the United States 80% of colon cancers are caused by genetic mutations in E coli (APC), a protein adenoma polyps Although most people with this mutation develop polyps, some of them can become cancerous, a phenomenon that is not fully understood The team decided to investigate non-
genetic factors that could lead to the disease, focusing on the role of the amino acid glutamine "Cancer cells need to consume a lot of glutamine to multiply," said Kong Mei, associate professor of molecular biology and biochemistry at But we found that depriving them of glutamine does not kill all tumor cells Some tumors cells to adapt, in fact, when their glutamine is in short supply, they become a more aggressive cancer researchers found that after glutamine starvation, the decline in cell metabolites, ketone-pyridelic acid, was accompanied by a shift between benign cells and cancer cells The findings prompted them to study the role of metabolites further When they provided modified versions of ketone diacids for animal models of APC mutations, the results were significant Only 23 percent of mice that received the modified metabolite had rectal bleeding, a sign of intestinal tumors, and 90 percent of mice that did not receive the metabolites had rectal bleeding It also inhibits the growth of tumors and prevents disease-related symptoms such as weight loss "Supplementing the modified ketone-diazepam inhibits a key cancer development signaling pathway in colon cancer cells, making them more normal cells," said Thai Q Tran, lead author of the paper It is also worth noting that we mix it with drinking water, so it is easy to take and does not affect overall health "
the team hopes to further study the modification of metabolites to explicitly target colon cancer cells Professor Kong said: "We believe this new finding shows that the use of less toxic and natural methods, combined with current treatments, can be more successful in treating colon cancer while better protecting the overall health of patients, with great potential." (biovalleybioon.com) References: Colon Colon cancer cancer
Thai Q Tran et al, alpha-Ketoglutarate attenuate Wnt ignaling and drive azaliin in color cancer, Nature Cancer (2020) DOI: 10.1038/43018-020-0035-5