Nature: Asstary glial cell-induced inflammation of the central nervous system is associated with gut microbes!

Asstar glial cells are rich cells in the central nervous system, which regulate nerve activity, synact formation and restrict the maintenance of blood-brain barrier in neuronal metabolism-related development and steady state in the body.
addition, astrological glial cells have the ability to promote and expand pathological responses to the central nervous system, such as neurotoxicity, as well as the ability to activate small glial cells and collect peripheral inflammatory cells.
, little is known about the steady-state anti-inflammatory activity of astrological glial cells and their regulatory mechanisms.
published online in the journal Nature, the Harvard Medical School's Francisco J. Quintana team named "Gut-licensed IFN plus NK cells drive LAMP1 plus TRAIL plus anti-ingy astrocytes."
mouse experiments have shown that LAMP1-TRAIL-asstary glial cells limit inflammation of the central nervous system (CNS) by inducing T-apoptosis, which is maintained by meninges IFN-NK cells and regulated by intestinal microorganisms.
to identify new sub-groups of astroid glial cells, the researchers used fluid cytometics to detect the binding of 266 antibodies to star-shaped glial cells in mice.
they found that the most abundant marker for spinal astrocyte expression was lysosome-related membrane protein 1 (LAMP1, also known as CD107a).
also, spinal cord-like glial cells were raised in mice with experimental autoimmune encephaloblastitis (EAE), while physical asantrogenic cells in the small brain, cortical or cortical were not.
analysis of astrocyte surface markers in EAE is a lysosome protein that can be detected in the cell membrane and is related to cytotoxic activity.
researchers used LAMP1 in lyovirus inactivated star glial cells to find an increase in the number of CD4-T cells expressing IFN-γ and/or interlebin 17 (IL-17) in CNS, and that the inflammatory pathways of astrocytes were activated.
but this treatment did not affect CD8-T cells and FOXP3-Treg cells.
researchers at the LAMP1 and Tnfsf10 levels in
astrology glial cells used RNA-seq analysis to find that the infestion of Lamp1 in astrology glial cells reduced the surface expression of TLAIL, a tumor necrosis factor (TNF)-related apoptosis-induced lilog, while other members of the TLAL and TNF families tended to regulate the immune response by inducing apoptosis.
with these findings, knocking out Tnfsf10 (TRAIL-coded genes) activates the inflammatory path path of astrological glial cells.
further studies of inflammatory paths in astrological glial cells have shown that LAMP1-TRAIL-asstary glial cells induce T-cell apoptosis through RAIL-DR5 signaling, thereby limiting inflammation in the central nervous system.
balance in the body, interferon-γ (IFN) in astrological glial cell killer cells is regulated by gut microorganisms and drives the expression of TRAIL in astrological glial cells.
when inflammation is formed, the molecules produced by T-cells and small glial cells inhibit THEIL expression in astrological glial cells.
NK cells inhibit RAIL expression In general, LAMP1-TRAIL-asstary glial cells limit CNS central nervous system (CNS) inflammation by inducing T-apoptosis, which is maintained by meninges IFN-NK cells and regulated by intestinal microorganisms.
this study shows the important role of astrological glial cells in CNS inflammation, and also points out the regulatory role of gut microorganisms in this pathway.
may be a new hope for CNS inflammation therapy in the future.