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Nature Aging: Naked mole rats reveal their age through epigenetics

 Last Update: 2022-01-08
 Source: Internet
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Model organisms are essential to aging research

This work was published in a paper in "Natural Aging", " DNA methylation clocks tick in naked mole rats but queens age more slowly than nonbreeders "

Naked mole rats have an extraordinary life span among rodents and can resist age-related diseases

Dr.

The team created a methylation "clock" unique to naked mole rats in the organization and found that the estimated age of methylation is very correlated with the chronological age

The team observed a strong epigenetic aging effect and developed 7 highly accurate appearances for several tissues (pan-tissue, blood, kidney, liver, skin clock) and two dual-species (human MRI) clocks Genetic clock

The authors concluded that although the observable characteristics of naked mole rats indicate that they are "unsenile" mammals, this species is indeed epigenetically senescent—similar to other mammals

They say that using epigenetic clocks can not only estimate the age of wild naked mole rats, but also help study their potential as model organisms for aging, longevity, and disease suppression

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