Natno Biotechl artificial womb significant progress! Scientists prove that bioengineered wombs can conceive!

, July 4, 2020 /PRNewswire/
-- In a new study by the Wake Forest Institute for Regenerative Medicine (WFIRM), scientists have shown that bioengineered wombs can support fertilization, fetal development and live births of normal offspringWith further development, this approach may one day provideregenerative medicinesolutions for women who are unable to conceive due to uterine dysfunctionIn a study publishedthe journal Nature Biotechnology, scientists demonstrated in animal models that bioengineered uteruses can develop the primary tissue-like structures needed to support normal reproductive functionAnthony Atala, M.D.,, said: "Research has shown that engineered uterine tissue can support normal pregnancy, that the fetus develops normally, and that the size and weight of the offspring are comparable to that of normal uterusAnthony Atala is the lead researcher on the study and director of WFIRMAs we develop, this approach may provide a way for women with uterine abnormalities to become pregnant"
picture source: The Wake Forest Institute for Regenerative Medicine (WFIRM)WFIRM scientists are a world leader in regenerative medicine, and some of the basic principles oftissue engineeringand regenerative medicine were first developed at the instituteTheir strategies for inoculating patients' own cells into biodegradable stents for functional tissue bioengineering have been effectively explored in preclinical studies and successfully applied to human patients to restore function in tubular and hollow non-tube organsRegenerative MedicineandTissue Engineeringtechnology has become an attractive option to overcome donor organ shortages and other limitations from donor transplantationScientists used the same bioengineering strategy to design the uterus, a more complex organ that requires more function in embryo implantation and fetal developmentin this study, the rabbits were randomly divided into four groups: (1)tissue engineeringuterine group, implanted stents using the animal's own cells;rabbit has long been used in reproductive biology research, compared with other experimental animals, the rabbit's uterus is relatively large, is the ideal object of uterine tissue regeneration researchThe uterus of a female rabbit is made up of two separate, functional uterine corners and a cervix, each with the ability to conceivebiodegradable polymer stents are customized for each animalThe cells needed to regenerate uterine tissue and implant stents are grown from the uterine structure of each rabbitAfter 6 months of stent implantation, natural mating with a male rabbit"The rabbit with the implants has a normal pregnancy in the reconstructed uterus," said co-author Renata SMagalhaes, M.D "This study provides new avenues for creating tissue substitutes from patients' own cells to treat uterine defects." Despite the need for anti-rejection therapy, transplants from the late and living donors to the uterus have shown the prospect of treatment for permanent uterine infertility so far, there are about 70 cases of uterine transplants worldwide In the United States, fewer than 10 babies are born through a uterus transplant The proposed strategy is to create uterine tissue from the patient's own cells, avoiding the need to transplant organs from deceased or living donors, and avoiding the risk of rejection and the need for anti-rejection drugs "Our results suggest that tissue engineering the uterus respond to expansion and mechanical strain that occur during pregnancy," said Koudy Williams, co-author of the paper "Further preclinical studies are being planned pending the of clinical trials." (BioValleyBioon.com) References: Scientists prove bioengineered uteri support smh.com
A-ged support sliving slivings in rabbits, Nature Biotechnology (2020) DOI: 10.1038/s41587-020-0547-7