Nat Metab: break cognition! The health effects of exercise can not be separated from fat!

February 12, 2019 / BIOON / - it has been known that exercise can improve health, but it is a question that researchers at the joint Diabetes Center (JDC) of Harvard University are trying to answer to find out how exercise can make the body healthier at the molecular level Photo source: after NAT Metab was tested in humans and mice, the researchers found that exercise can lead to dramatic changes in fat In addition, they found that these trained fats release healthy factors into the blood Relevant research results were published online in nature metabolism on February 11, 2019 It has been known that fat cells secrete proteins called adipokines, while many adipokines that increase with obesity have a negative impact on metabolism and health "Contrary to the negative effects of many fat factors, our study found that transforming growth factor beta 2 (TGF beta 2), as a fat factor produced by fat tissue in response to exercise, can actually improve glucose tolerance." Laurie J Goodyear, Ph.D., co-author of the study and head of the JDC integrated physiology and metabolism team The researchers found that not only exercise-induced tgf-beta-2 can improve glucose tolerance, but also the treatment of obese mice with tgf-beta-2 can reduce blood lipid levels and improve many of the body's metabolic capacity "We are impressed by the importance and significance of a protein." Goodyear says she is also a professor of medicine at Harvard Medical School Two years ago, the international team found for the first time that fat tissue has a good metabolic effect on exercise "We suspect that exercise alters adipose tissue, which causes the adipose tissue to release these beneficial proteins into the bloodstream Before that, we always focused on the positive effects of muscles " Based on these results, the team tried to find out the fat factors released by fat tissue during exercise So they did a series of experiments on human and mice They identified changes in blood fat factor levels in mice and humans before and after exercise Their analysis found that tgf-beta-2 is one of the up-regulated proteins after human and mouse exercise Subsequent experiments have shown that the content of this fat factor in fat tissue and blood will increase To determine if the protein had a positive effect, they treated obese mice with TGF-beta 2, which showed a range of positive effects, including glucose tolerance and increased fatty acid intake "Our results are very important because this is the first study to find that exercise-related fat factors are beneficial to metabolism." Goodyear said Other important findings include lactic acid, which also increases during exercise Muscle releases lactate during exercise, which is then transferred to fat to promote the release of TGF-beta 2 "This research has revolutionized our view of exercise and its many metabolic effects What's more, fat actually plays an important role in the process of exercise " These findings suggest that TGF beta 2 may be a potential therapy for hyperglycemia or even type 2 diabetes Of course, longer-term studies are needed to determine the safety of TGF-beta 2 therapy (BIOON Com) reference: Takahashi et al Tgf-b2 is an exercise induced adipokine that formulates glucose and pretty acid metabolism Nature metabolism, February 11, 2019 Doi: 10.1038/s42255-018-0030-7