Nat Med: Scientists clarify the mysterious link between obesity and type 2 diabetes

As we all know, obesity affects the body's insulin production, and over time will increase the body's risk of type 2 diabetes and a variety of other metabolic diseases; recently, an article was published in the international journal Nature Medicine entitled "Obesity and hyperinsulinemia Drive adipocytes to activate a cell cycle program and senesce" research report, scientists from Sweden’s Caroline College and other institutions have revealed the causes and molecular mechanisms of fat cells inducing metabolic diseases in the body through research.

The purity of isolated human adipocytes and the expression of cell cycle transcription profiles

Image source: Li, Q.

Nowadays, obesity has become a rapidly growing global public health problem, especially among children and young people.

Although this relationship has been established, the mechanism behind the enlargement of fat cells (adipocyte hypertrophy) and the secretion of pro-inflammatory substances is still unknown to researchers

The natural process of increasing the size of fat cells will have a variety of negative effects on the health of the body.

Using a common drug for the treatment of type 2 diabetes, researchers can effectively block the formation of senescent fat cells and reduce the release of pro-inflammatory factors based on fat cells

In summary, the results of this study show that the use of metformin to target the fat cell cycle program may affect the aging of fat cells and the occurrence of obesity-related adipose tissue inflammation

Note: The original text has been deleted

Original source:

Li, Q.