Nat Med: Developed a test method to quickly detect SARS-CoV-2 antibodies in human blood

2020 May 18 News /BioValleyBIOON / --- A new study describes a SARS-CoV-2 virus antibodies can be detected in the blood if there is test methodsThis test method is performed in 16 patients tested, may help identify individual plasma containing SARS-CoV-2 antibody, the antibody may be contained for treating other patientsResearch results in 2020, published online May 12 in the NatureMedicine journals, papers titled "AserologicalassaytodetectSARS-CoV-2seroconversioninhumans"SARS-CoV-2 under TEM (formerly called 2019-nCoV), the images from NIAIDRMLtest method of detecting the presence of SARS-CoV-2RNA is widely used for a diagnosisCOVID-19However, the test method is able to detect the presence of antibodies to the virus may help to determine the prevalence populationpapers corresponding author, FlorianKrammer United States Icahn School of Medicine at Mount Sinai and colleagues developed an enzyme-linked immunosorbent assay method can be used to detect the presence of SARS-CoV-2 antibodiesFor this test method, they are constructed on the spike protein found on the surface of the virus (S protein) of the two versionsS-mediated SARS-CoV-2 virus into the host cell, can be targeted antibodies that bind other coronavirus infection producedThe first version contains the complete S protein, while the second version is limited to the S protein receptor binding domain (a small portion of S protein)using 16 parts by plasma and serum samples (liquid component of blood) from the patient-CoV-2 SARS infection, researchers observed that all the samples that are two versions of the S protein has produced positive resultsOverall, they found that the reaction of the full-length protein S is stronger, this may indicate that there are more antibody binding sites on protein larger version SIn a test involving 50 parts collected from the participants before the SARS-CoV-2 outbreak serum samples (negative control), they found that the samples of these two versions of the S protein reaction is very low or no responseresearchers noted that their detection method is relatively quick, simple, does not involve handling live virusesHowever, they cautioned that the new study does not include those from severe acute respiratory syndrome coronavirus (SARS-CoV) or the Middle East breath samples coronavirus (MERS-CoV) syndrome patients, and therefore do not know for two coronal whether viral antibodies will produce positive resultsIn addition, research on a larger sample size is needed further(Biovalley Bioon.com)reference:1.FatimaAmanatetalAserologicalassaytodetectSARS-CoV-2seroconversioninhumans
.NatureMedicine, 2020, doi: 10.1038 / s41591-020-0913-5

2.SmallstudysuggestsCOVID-19antibodytestshowspromisehttps://medicalxpress.com/news/2020-05-small-covid-antibody.html