Nat Immunol: Scientists have discovered a new type of cell that can promote the regeneration of the central nervous system!

Neurodegenerative diseases are diseases of the central nervous system, including traumatic brain or spinal cord injury (SCI), multiple sclerosis, and motor neurone disease, caused by the loss of neurons or their myelin.
because of the poor regenerative capacity of the central nervous system, its injury rehabilitation is currently an international medical problem.
article published in Nature Immunology on October 26th, local time, offers new hope for curing these incurable central nervous system diseases.
ohio state university and the University of Michigan have discovered a new type of immune cell that not only saves damaged nerve cells from death, but also regenerates and repairs damaged nerve cells.
, the researchers identified human immune cell linees with similar characteristics that promote nervous system repair.
https://doi.org/10.1038/s41590-020-00813-0 The study's lead author, Dr. Andrew Sass of the Institute of Neuroscience at Ohio State University, said, "Our findings could eventually lead to the development of new immunotherapy that reverses central nerve damage and restores the nerve function lost in patients with various diseases."
strategy to promote neuropulation and regeneration is to regulate local immune responses to damage to the central nervous system.
when inflammation occurs in the body, neutral granulocytes go to the "battleground" and devour cells and bacteria.
While hyperactive neutropenia can exacerbate inflammatory damage in the case of multiple sclerosis, optic neurospinalitis, Alzheimer's disease and stroke, there is growing evidence that this may also be a breakthrough in improving neurological disorders.
Photo Source: In this experiment at Ohio State Wexner Medical Center, researchers found a new type of granulocyte that has the characteristics of immature neutral granulocytes, but has neuro-protection and neuroregenerative properties.
injecting these cells into mice with optic nerve damage or spinal cord nerve fiber damage can promote neuron survival and regeneration of retinal nerve cell axons.
this effect is achieved in part by secreting neurogrowth factors (NGF) and insulin-like growth factors (IGF-1).
after the new cells partially induced RMC axon growth by secreting growth factors, the researchers tested the ability of human bone marrow cells with immature neutral granulocyte characteristics to initiate nerve repair.
the transfer of these cells to the eyes of visually impaired mice with defective RAG1 genes directly stimulated the growth of fractured optic nerve cell axons.
Benjamin Segal, co-author of the report and a professor at Ohio State University's Institute of Neuroscience, said: "This growth factor secreted by the immunocellular subteum enhances the survival of post-traumatic nerve cells in the central nervous system and stimulates the regeneration of broken nerve fibers in the central nervous system, which is truly unprecedented.
"Next, the researchers will continue to explore the cells and amplification them in the lab to enhance the therapeutic effect."
hope that in the future these cells will help patients slow or stop the decline of sexual neurologic function.