Nat Immunol: 'Immune scar' after lung infection

2020 May 19 News / BioValley BIOON / --- according to a recent study, patients recover from serious lung infections over will have a "scar immunity", thus reduce the body's immune response and increase the risk of pneumoniaBased on the study of human and mice show that after some serious infections, the body's immune response to the temporary closure of the patient more susceptible to new bacterial or viral diseasesresearchers from the University of Melbourne found after severe infection, cells constituting the immune defense system of the first channel (macrophages) is "paralyzed." By analyzing blood samples of patients suffering from severe infections, the researchers found that their macrophages have been inactivatedThis makes patients more likely to be infected with the deadly secondary infections during hospitalization, such as pneumoniaFurther, studies have also determined the activation of macrophages "switch" is a name of SIRP-α receptor proteinActivation of the receptor will be restored to macrophages "full" state(Source: Www.pixabay.com)team says their findings could affect treatment of nosocomial infections, including the use of antibiotics in the system and so on"We think another way to treat the infection to the immune system is charged to get rid of paralysis, or prevent the occurrence of first paralyzed, so that patients can protect themselves against secondary infections without using antibiotics"
the research could have a significant impact on the future how to treat COVID-19 caseswe all know, the majority of deaths are due to COVID-19 cytokine storm caused, in this process, the body's own immune response began excesses, thereby causing acute or even fatal inflammatory effectsOneauthor of the article, AntoineRoquilly from Nantes University Hospital, said the temporary closure of a better understanding of the body's immune response SIRP-alpha and other immune switch "cytokine storm can prevent and improve survival in these patients"(Biovalley Bioon.com) Information Source: Scientistsdiscover'immunescars'onpatientswithlunginfections Original source: Alveolarmacrophagesareepigeneticallyalteredafterinflammation, leadingtolong-termlungimmunoparalysis,
NatureImmunology (2020) .DOI: 10.1038 / s41590-020-0673-x, / articles / s41590-020-0673-x