Nat Immunol: A New Breakthrough in Immunotherapy! Promising to improve cancer immunotherapy

May 11, 2020 /
prnewswire
BIOON / - Our immune system protects us not only from infection, but also from cancer This powerful protection is based on the activation of special cells of the immune system, CD8 plus T cells These cells identify infected cells or cancer cells and kill them Percy Knolle, professor of molecular immunology at the Technical University of Munich (TUM) in , explains: "The ability of the immune system in patients, especially CD8-T cells, to remove cancer cells from tissues such as lung, bowel and liver cancer is often limited image source: http://cn.bing.com
injections of antibodies can rejuvenate cancer patients' immune responses
send signals to cancer cells and slow their immune response Knowledge of how specific immunity from tumors is limited by these signals has led to the development of cancer immunotherapy suppressed through so-called checkpoints in this form of treatment, the signals sent by cancer cells are suppressed and cancer-specific immunity is released The use of antibodies to these signals ("checkpoint suppression") can often reactivate the patient's immune response to tumor newly discovered inhibitory mechanism to suppress cancer-specific immune response
Munich University's Batian H Dr Cht and the team led by Professor Percy Knolle and their partners have discovered a novel inhibitory mechanism that inhibits cancer-specific immune responses according to their recently published article, this inhibition is mediated by glucose metabolism decomposition products A special type of myelin immune cells (myelin-like inhibitory cells) that inhibit the activation of CD8-T cells are often found near and in tissues tumors It is well known that they severely limit cancer-specific immunity "We were able to determine that overproduction of glucose metabolite decomposition products was a feature of the inhibition cells in the tumor , while at the same time attributed cancer-specific immunity to this inhibitory metabolites," explained Dr Batian Hocht "
new method of activating immune cells
to kill cells in tumors
researchers have found that this inhibitory metabolite inhibits cancer-specific CD8-T cells by consuming the amino acids necessary for immune cell activation This suppressed immune cell still survives, but is inhibited in low metabolic activity states similar to hibernation researchers have successfully developed a way to wake up these "hibernating" immune cells The combination of "checkpoint suppression" and the suppression of the mid-sum of metabolites led to a strong increase in cancer-specific immune responses in experiments "These results will open the way for the development of new cancer immunotherapy," researchers said (biovalleybioon.com) References: Improving Atherapy for cancer
Baumann, T., Dunkel, A., Schmid, C et al.
Regulatory myeloid celle pell ei cell over-cell tranfer of the metabolite methylglyoxal Nat Immunol 21, 555-566 (2020) http://doi.org/10.1038/41590-020-0666-9