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The inflammasome is a cell membrane signaling complex that senses microbial ligands to induce inflammation and cell death in the body
The researchers said that the immune proteins, called guanylate-binding proteins (GBPs), may directly bind to and kill certain types of bacteria; in addition to providing a research basis for new treatments, these killer proteins also Can be combined with current antibiotics to give clinicians more options when treating certain types of infectious diseases
Researchers believe they can extract and harness the power of the GBP1 immune system protein to treat a range of infectious diseases without negatively affecting other cells in the body; disease-causing microbes will continue to adapt and overcome current drug therapies , so scientists need to constantly find new ways to develop more effective solutions
Researcher Professor Man said that for many years scientists had used antibiotics to treat a variety of different infectious diseases, and these antibiotics had become less effective over time as microbes continued to attack new or existing treatments.
Taken together, our findings demonstrate that GBPs can help differentiate between different pathogens and activate innate immunity, while providing a host-inspired blueprint to design synthetic antimicrobial peptides and help defend against emerging and re-emerging pathogens infection
Original source:
Feng, S.