Nat Commun: SOX2/GLI1-ST3GAL1-AXL pathline promotes melanoma metastasis

Malignant melanoma is the most invasive and therapeutic form of skin cancer.
invasive mainly because melanoma cells are highly metastasis even in the early stages of the disease.
Although recent treatment advances have shown that targeted therapies and immuno-checkpoint inhibitors can achieve long-term survival in a small percentage of patients with advanced melanoma, metastasis melanoma remains an incurable disease.
, identifying and targeting key drivers of melanoma metastasis is critical to effectively controlling tumor development.
SOX2/GLI1-ST3GAL1-AXL pathline mechanism in this study, the researchers reported a mechanism in which cancer-causing SOX2-GLI1 transcription complexes can regulate melanoma by mediating the salivary acid transfer enzyme ST3GAL1.
further studies have shown that ST3GAL1 can drive the metastasis of melanoma.
silence inhibits melanoma and significantly reduces the ability of invasive melanoma cells to enter the bloodstream, be implanted in distant organs, and survive in metastasis environments.
analysis of the expression of ST3GAL1 in skin melanoma and its development with melanoma showed that the subject tyrosine kinase AXL was the main effect factor of ST3GAL1 invasive function.
ST3GAL1 can induce the dijurification and activation of AXL, which in turn promotes the immersion of melanoma.
all, the results show that the ST3GAL1-AXL pathline is the key to driving melanoma metastasis, targeting that path path or potential treatment strategy for metastasis melanoma.
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