Nat Commun: Short-term fasting/fasting simulated diet can aid new complementary chemotherapy for breast cancer!

, June 28, 2020 /
PRNewswire/
-- There is plenty of preclinical evidence that short-term fasting and fasting simulated diets (FMDs) protect healthy cells from a variety of stressors, including chemotherapy, while making cancer cells more sensitive to chemotherapy and other therapiesIn essence, fasting causes healthy cells to change from proliferative to maintenance and repairOn the contrary, because of the activity of cancer protein, malignant cells do not seem to be able to enter this state of protection, and therefore can not adapt to nutritional deficienciesFasting deprives proliferative cancer cells of nutrients, growth and other factors, making them more sensitive to cancer treatment, which increases cell deathseveral previous small clinical studies have shown that fasting as an aid to chemotherapy is safe and well tolerated, and may reduce the toxicity of chemotherapyRecently, a multicenter, open-label, random DIRECT study (NCT021264449) was conducted in collaboration with members of the NetherlandsCancer Research Group, a team led by Judith RKroep of the Department of MedicineOncologyat Leiden University Medical Center, and the results of the study, published in the Journal of "Climate neoadjuvanty for cancer in the multi-centre dydd phase phase 2 DIRECT trial"Photo Source: Thisclinical trialrecruited 131 HER2-negative stage II/III breast cancer patients with nodiabeteswith a BMI greater than 18 kg/m2The researchers randomly divided the patients into two groups, using a fasting simulated diet (N-65, with an average age of 49) or a regular diet (N-64, with an average age of 51) three days before receiving new complementary chemotherapy and during treatmentresearchers found no significant difference in toxicity between the two groups, although the fasting simulated diet group did not receive dexamethasoneBut the researchers found that the FMD group (OR 3.168, P?? What's the 0.039) Patients have a higher proportion of full or partial radiation responsesthe researchers found by programme analysis that patients in the FMD group (OR 4.109, P? What's the 0.016) is more likely to have a 90-100%tumorcell reduction of the Miller-Payne 4/5 pathological responseIn addition, FMD can significantly inhibit T lymphocyte DNA damage caused by chemotherapyin general, the results of this study show for the first time that FMD is safe and effective as an auxiliary treatment for chemotherapy in patients with early breast cancerThese findings and preclinical data encourage further exploration of the benefits of fasting/mouth FMD for patients receiving extensive cancer treatment(BioValleyBioon.com)References:de Groot, S., Lugtenberg, R.T., Cohen, Det al.
Fasting mimicking diet as an adjunct to? Neoadjuvantford cancer in the multi-centre dydd 2 directNat Commun 11, 3083 (2020)https://doi.org/10.1038/s41467-020-16138-3
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