Nat Commun: Neuronal aging can exacerbate DNA damage

2020 Nian 5 Yue 19 hearing / BioValley BIOON / --- Recently, neuroscientists at MIT found that an enzyme called HDAC1 is essential to age-related DNA damage to repairEarlier studies have shown that Alzheimer's patients and healthy elderly, the enzyme content usually decreasesstudies on mice, researchers have shown that when HDAC1 lost with age in mice, DNA damage can accumulate a particular typeThey also showed that they can activate HDAC1 drugs to reverse this damage and improve cognitive functionThe researchers said the study showed that HDAC1 might restore people to Alzheimer's disease patients and age-related cognitive decline have positive benefits(Source: Www.pixabay.com)Picower research scientist at the Institute of Ping-ChiehPao is the main author of the study, the study published today in the "NatureCommunications" magazineHDAC enzyme family has several members whose primary function is to modify histones, thereby regulating gene expression2013, the authors laboratory published two papers, the DNA HDAC1 and repair of neurons linkedThe latest study, researchers explored when HDAC1-mediated repair fails what happensTo this end, they were engineered mice, the mice neurons and astrocytes in the absence of HDAC1 selectivitycompared to normal mice, during the first months of life, the brain cells in transgenic mice transfected DNA damage levels and no significant difference in behaviorHowever, increasing age, these differences become apparentDNA damage in the absence of HDAC1 start of mice accumulate, they also lose the ability to regulate synaptic plasticityThe lack HCAC1 old mice also showed spatial memory and navigation damage testresearchers found, HDACl can cause loss of a specific type of DNA damage, known as 8-oxo - guanine damage, which is a sign of oxidative DNA damageBased on the study of Alzheimer's disease patients show that this type of DNA damage in the patient's body type is very common, and often harmful metabolic byproducts arising from the accumulationThe brain's ability to remove these by-products typically decrease with ageOGG1 enzyme responsiblecalled oxidative DNA damage repair of this type, the researchers found that activation HGG1 need HDAC1In the absence of HDAC1, OGG1 can not be opened, DNA damage can not be repairedThe researchers found that the most sensitive to this type of damage to many of the genes responsible for the expression of ion channel proteins, and these channel proteins essential for synaptic function(Biovalley Bioon.com)Information Source:StudyfindsthatagingneuronsaccumulateDNAdamageOriginal source:Pao, P., Patnaik, D., Watson, LAetal <br /> HDAC1modulatesOGG1-initiatedoxidativeDNAdamagerepairintheagingbrainandAlzheimer'sdiseaseNatCommun11,2484 (2020) .https://doi.org/10.1038/s41467-020-16361-y