Nat Commun: Intestinal bacteria play a key role in brain function and body mood regulation!

17, 2020 // -- In a recent study published in the international journal Nature Communications, scientists from the Pasteur Institute and others found that imbalances in the gut microbiome may contribute to a decline in the levels of certain metabolites, leading to depressive behavior in the body.
group of bacteria in the gut, commonly known as the "intestinal bacterium", is the largest reservoir of bacteria in the body, and now more and more research shows that the host and gut bacterium are good examples of a mutually beneficial interaction, and recent observational findings have revealed the body's mood disorders and intestinal bacteria. The link between injury comes after researchers found a link between gut bacteria and the molecular physiency of fluoxetine, a molecule commonly used as a depression drug, but researchers do not yet know the molecular mechanisms that control the development of depression, which is now a major cause of disability in the global population.
Photo Source: Pascal Marseaud used animal models for research, and researchers found that changes in the gut microbiome caused by chronic stress may lead to depression-like behavior in the body, especially as it promotes a decline in lipid metabolite levels in the body's blood and brain.
these lipid metabolites, called endogenous cannabinoids, may coordinate the body's communication system, which is severely hampered by decreased metabolite levels, and gut microbiomes play a key role in brain function and mood regulation.
endogenetic cannabinol binds to a subject that is the primary target of THC (tyhydrocannabinol), the most well-known active ingredient in cannabis.
scientists have found that the absence of endogeneic cannabinin in the body, a key brain region of the brain involved in memory and mood formation, may lead to the appearance of depression-like behavior in the body.
Scientists obtained these results by studying the microbiomes of healthy animals and animals with mood disorders, said researcher Pierre-Marie Lledo, who said it was surprising that simply transferring the microbiomes of mood disorder animals to healthy animal bodies was enough to induce the latter to have biopic changes in the body and produce depressive behavior.
researchers found that certain bacterial bacteriocytes decreased significantly in animal bodies with mood disorders, and later found that oral therapy based on the same bacteria restored normal levels of lipid metabolites, thereby slowing depression-like behavior.
the bacteria may also be used as an antidepressant, and such therapies are also known as "psychobiotics."
The researchers concluded that the results of this paper illustrate the role of the gut microbiome in the functioning of the normal brain function, if the body's gut microbiome function imbalance, some of the lipids that are critical to brain function may disappear, thus promoting the occurrence of depressive behavior, in this particular case, the use of special bacteria or as a potential therapy to restore the body's healthy microbiome and more effective treatment of mood disorders.
original source: Chevalier, G., Siopi, E., Guenin-Macé, L. et al. Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system. Nat Commun 11, 6363 (2020). doi:10.1038/s41467-020-19931-2。