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Nat Commun: Identification of fecal microbial markers in the early detection of colorectal cancer

 Last Update: 2021-05-31
 Source: Internet
 Author: User

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Colorectal cancer (CRC) is one of the most common cancers, and the overall mortality rate of patients is very high.

It is estimated that the national expenditure on cancer care, especially colorectal cancer, in the United States in 2018 was about 16.

Colorectal adenomas are considered to be the precursors of most CRCs.

The gut microbiome is a non-invasive biomarker based on fecal metabolites, which can be used to analyze metabolic diseases and cancer.

Changes in the composition of intestinal microbes in different disease states

In this study, the researchers conducted a comprehensive analysis of 1,056 public stool samples to identify microbial markers associated with adenomas for early detection of CRC.

Differentiate adenoma from control or cancer by important characteristics

In addition, the researchers verified the effect of the classifier in two independent cohorts, and the AUC (the area under the ROC curve) values were 0.

Further studies have shown that the main microbiome characteristics that have changed are increased biosynthesis of ADP-L-glycerol-β-D-mannoheptose in adenomas, and increased biosynthesis of menaquinone-10 in CRC.

org/10.

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