Nat Commun: Genomics of worsening pancreatic cysts.

Pancreatic cancer is a deadly and poor prognosis disease, and like other epitheliotic malignancies, pancreatic cancer is caused by noninvasive precancer lesions that can be cured if detected and treated early.
Although most pancreatic cancers are thought to originate from tiny precancer lesions (endodergioma, PanIN), current imaging techniques can detect only some large cysts, including intra-catheterized papillomatosis (IPMN) and mucus cysts (MCN), which also contribute to the prevention of infested pancreatic cancer.
But since the development of these tumors is not clear, there is an urgent need to understand the molecular mechanisms and potential biomarkers associated with the development of immersive tumors in order to better identify cysts that are at high risk of cancer and require clinical intervention.
the study analyzed a total of 148 samples of IPMN, MCN, and small-related leaching cancers from 18 patients using an all-outer prosyntic group or targeted sequencing.
analysis shows that both IPMNs and MCNs are direct prescroles to pancreatic cancer.
researchers found that SMAD4 and TGFBR2 mutations usually occur only in immersive cancer, while RNF43 mutations occur mainly in non-immersive lesions.
analysis showed that the average time interval between highly atypical hyperplectomy and the occurrence of pancreatic cancer was more than three years.
the results show that non-immersive IPMN and MCN are the origin of immersive pancreatic cancer, identify potential leaching drivers, reveal the complex cloning dynamic process before tumor malignant transformation, and provide data support for early detection and intervention of cancer.
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