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Breast cancer is a major disease affecting women around the world, and its morbidity and mortality are increasing year by year.
Breast Cancer Triple Negative Breast Cancer (TNBC) is defined as the lack of expression of ER (estrogen receptor), PR (progesterone receptor) and HER2 (human epidermal growth factor receptor 2).
TNBC is associated with aggressive pathological features, including high histological scores, high mitotic index, higher metastasis and recurrence rates, lack of targeted therapy, and poor prognosis of patients.
The use of genome editing systems (such as CRISPR/Cas9 technology) for genome-wide genetic screening has become an advanced tool for systematically characterizing cancer susceptibility.
Genome editing system (such as CRISPR/Cas9 technology) for genome-wide genetic screening Genome editing system (such as CRISPR/Cas9 technology) for genome-wide genetic screening screening
TNBC's genome-wide CRISPR knockout screening
TNBC's genome-wide CRISPR knockout screeningThe study revealed that mTOR signaling pathway and Hippo signaling pathway are essential components for regulating tumor function in TNBC patients .
The study revealed that mTOR signaling pathway and Hippo signaling pathway in TNBC patients are essential components for regulating tumor function.
The activation of the mTOR pathway promotes the occurrence of TNBC
The activation of the mTOR pathway promotes the occurrence of TNBCAll in all, the results of this study reveal the power of genome-wide CRISPR screening in vivo in identifying clinically relevant and novel cancer treatment strategies.
The results of this study reveal the powerful function of genome-wide CRISPR screening in vivo in identifying clinically relevant and novel cancer treatment strategies.
org/10.
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