NAT COMMUN: Fasting plus Vc, anti-cancer combination
-
Last Update: 2020-05-29
-
Source: Internet
-
Author: User
Search more information of high quality chemicals, good prices and reliable suppliers, visit
www.echemi.com
The hunger-simulated diet can slow tumor progression and make multiple tumors sensitive to chemotherapy, but so far we do not know much about the therapeutic potential of its combination with noncytotoxic compoundsrecently, researchers found that the anticancer activity of vitamin C was limited by an increase in stress-induced protein hemoglobin-oxyase-1In THE KRAS-mutated cancer cells, the fasting simulated diet can choose to reverse the increase in vitamin C-induced hemoglobin-oxidase-1 and ferritin, thereby increasing reactive iron, reactive oxygen and cell deathMoreover, this effect is further enhanced by chemotherapyto support the potential role of ferritin in the progression of colorectal cancer, analysis of the Cancer Genome Atlas database showed that if the levels of ferritin mRNA in patients with KRAS mutation were low, they would have a longer total survival of 3 years and 5 yearsoverall, the data show that the combination of an empty stomach simulated diet and vitamin C represents a promising low-toxic intervention that will be tested in randomized clinical trials of colorectal cancer and other tumors with possible KRAS mutations
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to
service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.
