NAT COMMUN: Case study shows APOE2 reduces risk of Alzheimer's disease
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Last Update: 2020-05-30
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Source: Internet
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Author: User
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Previous studies have shown that every additional copy of the lipoprotein E4 (APOE4) allele is associated with an increased risk of Alzheimer's disease, while the APOE2 alleles are associated with a lower risk of Alzheimer's diseaseBut so far, it is not clear whether APOE2 pure-combination genetics have a particularly low riskSo researchers recently studied the likelihood of Alzheimer's disease and other aspects in more than 5,000 cases and controls of Alzheimer's disease with clinical and neuropathic characteristicsthe apoE2/2 genotype had a lower risk of developing Alzheimer's disease than APOE2/3 and 3/3The APOE2/2 genotype is particularly less likely to develop Alzheimer's disease than APOE4/4In the neuropathologically confirmed groups, the effects of the dose slots of aPOE2 and APOE4 gene were significantly greater than those of more than 24,000 cases of neuropathic unconfirmed cases and control groupsto identify and target factors that affect Alzheimer's disease in the, and may have a significant impact on understanding, treating and preventing Alzheimer's disease
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