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August 27, 2020 /--- -- Blood replacement therapy protects the brains of mice from isoemia, according to a new study by Dr. Shufang Ren, a neuroscientist at the University of West Virginia.
their article was published in Nature Communications.
the study is believed to be the first to show that blood replacement therapy can improve stroke outcomes in mice, potentially having implications for the treatment of stroke in humans.
strokes (isoemia) occur when blood supply to the brain is interrupted, usually with blockages in the arteries that lead to the brain.
only treatment for ISIC-approved stroke is tPA or tissue lysolysase activator, which dissolves blood clots and improves blood flow.
, tPA is usually taken within three hours of a stroke.
that blood transfusions can be performed over a limited time range (up to seven hours) and can still have a positive impact.
20 percent of the blood in the replacement mice was enough to significantly reduce damage to the brain.
(Photo: www.pixabay.com) researchers explain that after a stroke, the composition of the patient's blood changes, causing damage to the way the brain and body react.
neutral granulocytes help guide the immune system's response, but at the same time the cells cause blood-brain barrier leaks and brain tissue degeneration by secreting an enzyme called MMP-9.
results show that blood replacement therapy eliminates inflammatory cells after stroke and lowers levels of neutral granulocytes and MMP-9.
"What we've learned is that stroke is not a cerebrovascular event at all.
it was a whole-body event.
the brain and body receive signals.
immune system actually leads to a further deterioration of the disease.
, good results will be obtained through blood replacement therapy.
, more than 795,000 Americans suffer from stroke each year, 140,000 of them from stroke, according to the Centers for Disease Control and Prevention.
(bioon.com) Source: New blood, new hope: Transfusions protect the brain from the original source of the from the stroke: Ren, X., Hu, H., Farooqi, I. et al. Blood substitution therapy rescues the brain of mice from ischemic damage. Nat Commun 11, 4078 (2020). doi.org/10.1038/s41467-020-17930-x.
